Answer : 4. "Cursed"
Explanation :

The most appropriate antonym for the underlined word "blessed" in the given sentence is "cursed." "Blessed" implies being favored, protected, or endowed with divine grace, while "cursed" suggests being subjected to divine displeasure or misfortune. The other options— "appointed" (designated for a specific role), "produced" (created), and "applied" (put into action)— do not convey the opposite meaning of "blessed" in this context.